In his debut, Lloyd will face the New York Mets at 9:10 p.m. (CDT) in Petco Park in San Diego, California.
Cespedes' check-swing triple in the seventh inning was the difference.
"It stinks to put your team in a position like that and the third inning be down by six runs, but I have got to stay positive", Matz said.
Cespedes exited the game after running the bases with a sore quadriceps, which isn't considered serious.
"If you don't locate, you're going to get knocked around in this league", Mets manager Terry Collins said. When the ball got away, Cespedes headed home and scored when Padres catcher Hector Sanchez couldn't corral the throw from left fielder Jose Pirela.
Jacob DeGrom was outstanding once again, winning his eighth straight start and improving his record to 12-3 while Clayton Richard took the loss for San Diego, dropping to 5-11.
Matz's early struggles continued a trend: Entering play he had pitched to a 6.55 ERA, with batters hitting.323, in innings one through three. He struck out one.
"Overall, I think I had a pretty good bad day", he said. The nadir during that stretch was the nine hits he allowed over one-plus innings against the Rockies on July 16, when he was removed after allowing seven runs. The right-hander walked three and struck out five in lifting his home mark to 6-2.
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"It's a tough one to lose by a couple inches", manager Andy Green said. "He was a guy who worked extremely hard both on the field and off the field and he was a great teammate".
Myers' fifth-inning sacrifice fly tied the score at 4.
The Mets chased Lloyd in the fifth after Granderson and Cabrera delivered consecutive doubles. They extended the lead to 3-0 on RBI hits by Yoenis Cespedes and Jay Bruce. After Lucas Duda and Jose Reyes lined out, Travis d'Arnaud, the No. 8 hitter, singled home Bruce to make it 3-2.
Flores smacked a home run in the second for a 1-0 lead. Lucas Duda is 3-for-6 with two homers against Chacin, who has gone 1-5 with a 6.50 ERA in eight career games (seven starts) against the Mets.
Will the Mets and Padres go over the betting total tonight at 10:10PM ET when they clash at Petco Park? "I want to pitch into the ninth every game", he said.
Mets: Collins said RHP Jeurys Familia (blood clot, right arm) is playing catch and will be moving to the mound soon. Earlier this season, Mets GM Sandy Alderson said they are going to have to be hyper-aware that Cespedes is prone to leg issues because of his physique.
Padres: 2B Yangervis Solarte, a switch-hitter sidelined by a strained left oblique muscle, is set to begin swinging from the right side Monday. C Austin Hedges (concussion) is doing baseball activities, but there is no timetable for his return.
The righty allowed four hits and two runs with five strike outs in 5.1 innings of work.