Murphy was already slated to miss the first four games of the season after being suspended for violating the NFL's PEDs policy.
He started vs. the Baltimore Ravens on Thursday night and played through several possessions in the first quarter.
The Redskins wanted to be creative with their outside linebackers, with both Smith and Murphy capable of playing inside in certain packages - as they did on occasion in 2016. He was helped off the field by members of Washington's medical staff and didn't speak to the media after the game. He didn't talk to reporters after the game, but Murphy left the visitors' locker room on crutches with his left knee heavily wrapped.
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Washington was already going to be without pass-rusher Trent Murphy for the first four games of the 2017 season, but now its outside linebacker will be on the sideline for the entire year. He recorded nine sacks, which almost doubled his two-year total coming into last season.
A former college star will be out for the upcoming National Football League season. The Redskins have stalwart Ryan Kerrigan as a starter but are presently without a healthy Preston Smith or Junior Galette.