Tottenham manager Mauricio Pochettino is also unlikely to risk new signing Serge Aurier against Everton, as the Ivory Coast global will only return to the club from worldwide duty later on Thursday.
The Lilywhites head into the game after having conceded a late equaliser to draw with Burnley at Wembley in their most recent top flight outing before the global break.
It will be interesting to see if Ronald Koeman perseveres with the 3-4-2-1 formation that so dramatically failed in the recent defeat to Chelsea, or plumps for last season's favoured 4-2-3-1 system in an attempt to inject more life into Everton's rather static attack.
Bookmakers believe in the victory of Everton in this meeting with difficulty, since the spurs, even despite the Ligochempionovic match with Borussia, urgently need glasses in the Premier League in order not to let go of the other overclocked favorites of the Premier League.
The former Celtic and Southampton man also withdrew from Kenya's squad for the friendly against Mozambique last weekend.
"It was really tough for him to play two full games for us in such a short period, then he travelled with his national team as well".
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Everton have made a mixed start to the season, taking four points from their first three Premier League games, and will be determined to prevail against Tottenham.
It promises to be an underrated encounter, and whoever wins that particular skirmish could have a massive say on where the points end up come 5pm. It's true that in the last game at Wembley we were disappointed with the result.
"He's a very smart player and I think he can definitely help to take Everton to the next level".
"It is an example of how we need to make the next step as Everton".
Wanyama suffered a knee injury in training prior to Spurs' draw with Burnley last month.
A similarly tight encounter should be expected this time around as the pair attempt to get back on winning ways in the league.
The global break was certainly more eventful than usual, what with the chaotic, last gasp scramble of deadline day followed up by Wayne Rooney's late night indiscretions.