LONDON, ENGLAND - MAY 27: Per Mertesacker of Arsenal and Arsene Wenger, Manager of Arsenal speak prior to The Emirates FA Cup Final between Arsenal and Chelsea at Wembley Stadium on May 27, 2017 in London, England.
Arsenal defender Shkodran Mustafi has been ruled out of action for up to six weeks after sustaining a thigh injury on worldwide duty.
The centre-back picked up the injury in Germany's 5-1 victory over Azerbaijan on Sunday, when he was forced off after 36 minutes.
"I don't think he will be available before the next worldwide break".
The former Schalke 04 man has made six appearances in all competitions during the current campaign. At the moment, he's not available.
Kolasinac only managed one half while in action for Bosnia-Herzegovina against Belgium due to a hip injury, while Koscielny is set for a late fitness test on an Achilles injury.
"He trained on his own and the signs were positive so we will test him on Friday".
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Alexis Sanchez will not report back from worldwide duty with Chile until Friday, but Wenger has no concerns over the forward or Aaron Ramsey's mental state after their World Cup exits.
"The minor problem we have is with Sead Kolasinac".
"It was a very physical game".
"That is my understanding (that he wants to stay). At the present time there is no deal close for me to announce".
With Calum Chambers also sidelined through injury it could mean Arsenal go into the Watford match without four senior defenders.
The Blues are away to Crystal Palace, yet to even score in their seven successive defeats this season let alone take any points, while the Gunners make the short trip to Watford in their match.