United midfielders Michael Carrick (calf) and Paul Pogba (hamstring) have been injured since September while long-term absentees Zlatan Ibrahimovic and Marcos Rojo, who sustained knee injuries last season, are yet to recover.
The France global has been sidelined since September 12 after picking up a hamstring injury against Basel in the Champions League.
Rojo - another sufferer of the maligned cruciate knee ligament injury - is expected to resume full training himself at some point in November, but both he and Ibrahimovic won't be rushed back into action in case lengthy setbacks arise.
United are back in action after the global break when Mourinho's men host Newcastle in the Premier League.
United have been without Zlatan Ibrahimovic this season, with the superstar Swede sidelined with a knee injury.
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And the Portuguese, speaking after the 1-0 defeat to Chelsea, noted that the pair were on course to return ahead of a busy Christmas period.
The manager said he is hopeful his injured players will return to fitness after the global break.
"We have the group of players which are the ones that we hope will recover as soon as possible", he told MUTV.
United have 13 players away on global duty including Nemanja Matic, who is set to fly to the Far East with Serbia for friendlies against China and South Korea.
"They (international players) all disappear and then we have a couple. like (Chris) Smalling and (Ander) Herrera and they really deserve, after so many matches, to have a week off which I'm going to give them", Mourinho said.