Harry Kane, Dele Alli and Harry Winks have all pulled out and returned to Tottenham, while Kyle Walker, Fabian Delph and Jordan Henderson are also absent. Both him and Harry Winks were scanned.
"I have worked with the majority of them at younger levels".
"Spurs might risk them for the game with Arsenal, it's a different matter".
"I want them individually to be as successful as they can and keep them improving, but I'm not here to make them happy".
"I am hearing this talk of club v country but it is a nonsense", said Southgate.
Low is determined to use the match - and the subsequent clash with France - to experiment with his tactics ahead of his side's World Cup title defence in Russian Federation.
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Uncapped Burnley midfielder Jack Cork was brought in on Tuesday following the latest batch of withdrawals rather than the likes of Jack Wilshere, Jonjo Shelvey or Drinkwater.
'The players are injured and can not play, ' Southgate told BBC Radio 5 live.
"If he does feel 100 percent he could get a break for a game because he plays constantly, every three days throughout the season".
"I think Jonjo is a different type of player - plays deeper, receives very deep, plays nearly in a quarter-back position for his club".
Cork bolsters a midfield that Press Association Sport understands uncapped Ruben Loftus-Cheek - now on loan at Crystal Palace from Chelsea - will start as part of against Germany on Friday.
The Three Lions boss has been forced to reshuffle his squad following a succession of injury problems that have seen six players withdraw.
England goalkeeper Jack Butland during a training session at St George's Park, Burton. I took Marcel Halstenberg with us for that reason.