It was the Eagles' first defeat since a 27-20 setback at Kansas City on September 17. The loss is the Eagles first in nine games.
The offense, defense and coaching staff shared the blame. It was the first first-quarter touchdown allowed by the Eagles this season.
Russell Wilson is the king of December.
Wentz ended 29-of-45 for 348 yards with a touchdown and an interception. Eagle defensive coordinator Jim Schwartz had Wilson backpedaling and running for much of the drive. Pederson failed to challenge a questionable lateral by Wilson that led to Seattle's final touchdown.
The Seahawks (8-4) answered every Eagles rally with one of their own.
The Seahawks benefitted from a controversial non-call earlier in the drive. He had five receptions for 84 yards to pace the Seahawks receiving corps, and got back to his productive self as the Seahawks get ready for a push to the postseason.
Ertz has been a favorite target of Carson Wentz's this season.
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Philadelphia's first two trips to the red zone resulted in a 26-yard field goal by kicker Jake Elliott and a fumble by Wentz on the one-yard line.
He remained on the ground and appeared dazed following a hit over the middle by safety Bradley McDougled in the third quarter. It trickled out of the back for a touchback.
The biggest of them was one of those back-breakers that Wilson has made a specialty throughout his career, Wentz weaving his way through traffic in a deteriorating pocket and keeping his eyes downfield long enough to spot Nelson Agholor getting a couple of steps ahead of his man on the back side of the play. They also fell behind Kansas City by 14 during a 27-20 loss on September 17. Mike Davis dropped hints that he might be the tailback the Seahawks have been looking for, carrying the ball 16 times for 64 yards and catching four passes for 37 yards.
Wentz's astounding accuracy, the defense's dominance and the Eagles' jubilant celebrations that emerged week after week for the past two months were nowhere to be found in Seattle. They also fell behind Washington 3-0 on October 23 before rallying for a 34-24 victory. The Eagles lost for the first time since Week 2 and now sit at 10-2 on the year.
Seattle grabbed a 3-0 lead on its opening possession. The Seahawks took the first offensive possession down the field for a field goal and a couple of possessions later put together a touchdown drive.
Wentz offered plenty of reminders of the X factors he himself brings, including a couple of huge throws on a quick 81-yard march down the field in the early minutes of the fourth quarter.
Referee Tony Corrente and his crew hit the Eagles with 44 yards' worth of penalties in the first quarter.