Mourinho also told ManUtd.com that he'll make some changes to his starting eleven with Sergio Romero set for a start in goal with David De Gea given a well-earned rest following his superb performance at the Emirates.
"City bring their full-backs in narrow while two centre-backs push up the pitch, [so United could] just leave two strikers stretched wide and you play three central midfielders and five at the back, and say to City that's what we'll do, trust that the front two will get into those areas".
Pogba returned to Manchester United after a long-term injury that forced him to miss seven Manchester United games in the Premier League.
Luke Shaw will be named in the squad but Mourinho is still debating whether to give the left back a first start of the season.
"We have problems, we have injuries", Jose said. I know him a little bit. A couple of others guys are playing every match and they also need a rest. A player of incredible composure himself, Lampard is effectively telling Pogba: listen to the manager, take it on, if you disagree with it or are unhappy, speak about it afterwards but don't let it affect your game.
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Villarreal's Congolese striker Cedric Bakambu joined the fun and tweeted an image of a busted-up IPhone with the message: "You need to call De Gea to save this one".
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"When the period for that hard work comes, fatigue comes".
"He's [Shaw] working to have an opportunity and sooner or later, the opportunity will arrive".
"The next match is the match that matters".
The 24-year-old France global said last week he hoped "very important" City players would suffer injuries in the title race.
"Selected tomorrow - for sure. To start or to be on the bench, I can not answer".
United are top of Group A although their qualification is not mathematically guaranteed so Mourinho will not be taking too many risks on Tuesday night.