Police said the suspected shooter was "down" and did not give the conditions of the two victims in a press conference this morning.
The sheriff's office urged people to avoid the area and confirmed the school was evacauted.
All students at Aztec High School in Aztec, New Mexico, were being evacuated, police said, and no information on those shot was immediately available.
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The shooting happened early Thursday at Aztec High School, a school with about 1,000 students near the Colorado border. He did not say whether anyone had been injured or killed. Both Bloomfield and Farmington High Schools are on lockdown.
The nearby city of Bloomfield has placed its schools on lockdown as a precautionary measure and is asking parents stay away until further notice.
This story is developing.