Police told HuffPost they were unsure whether the reported explosion was inside the Port Authority building or the subway system.
The explosion, which happened around 7:30 a.m., triggered a massive emergency response by NY police and fire both above and below ground, tangling subway and bus service at the nearby Port Authority bus terminal.
ABC reports that it was a possible pipe bomb denoted below the bus depot. According to reports, the U.S. police has taken a man into custody, who they believe was carrying an explosive material that went off.
Multiple train lines are being evacuated.
Authorities are responding to a report of an explosion near Times Square.
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A law enforcement official says what is believed to be an explosive device has been set off on a Manhattan subway platform. The A, C and E line were being evacuated as police searched for any additional explosives.
The explosion happened in an underground passageway under 42nd Street between Seventh and Eighth Avenues, police said.
White House Press Secretary Sarah Sanders tweeted that President Donald Trump had been briefed on the explosion.
Francisco Ramirez said he heard two explosions as he was exiting a bus about 7:45 a.m. ET.