All lanes of I-65 are closed.
Indiana State police Sgt. Stephen Wheeles says work by responding agencies made the road safe for traffic until a permanent fix can be made.
Westbound traffic is being diverted off at Grant Street and eastbound traffic is being diverted off at Cline Avenue, police said. It was not immediately clear how long the closure would last.
Although cleanup crews were on scene earlier, the danger level escalated to the point that police are now letting the fire burn itself out. Any home withing a half-mile of the crash was evacuated.
The crash occurred about 4:30 a.m. about 40 miles north of Louisville, Kentucky. Southbound lanes remained closed until 9pm.
Strong winds continue to batter East Midlands
A spokesman for the Met Office said: "Public transport may be disrupted or cancelled and some bridges are likely to be closed". The forecaster says it will remain extremely windy on Wednesday morning with stormy conditions in the west.
Thomas Lemar and Leon Bailey
Arsenal and Liverpool have received a big boost in their pursuit of Monaco star Thomas Lemar , as boss Leonardo Jardim hints that he could leave.
Wounded Colorado deputies had to crawl to safety
Following reports of shots fired, the sheriff's office issued a code red and instructed residents in the area to shelter in place. A law enforcement motorcade accompanied the fallen officer from a hospital in nearby Littleton to the coroner's office on Sunday.
As a result of the crash, some of the chemicals from Okpeh's vehicle spilled inside the trailer and onto the roadway.
Authorities say the collision caused one of the trailers to leak a hazardous chemical, and eventually at least one of the rigs caught fire, sending black smoke billowing into the air. NIPSCO notified police the soonest the road could reopen is approximately 11:30 a.m. Police are urging drivers to seek alternate routes as there is a risk of explosion due to the leaking semi being fully engulfed in flames.
Department of Environmental Management.
The investigation is ongoing.