BRCA Status Doesn't Affect Survival in Young-Onset Breast Cancer

BRCA Status Doesn't Affect Survival in Young-Onset Breast Cancer

BRCA Status Doesn't Affect Survival in Young-Onset Breast Cancer

About 12 percent of the patients had a BRCA mutation, yet again confirming the association between this "faulty gene" and breast cancer. A total of 12 per cent of the women in the study carried the BRCA mutation.

In addition, a subgroup analysis of 558 women with triple-negative breast cancer suggested that women with a BRCA mutation may initially have a survival advantage during the few years after diagnosis.

Located within Penn Medicine's Abramson Cancer Center, The Basser Research Center for BRCA focuses exclusively on BRCA1 and BRCA2.

BRCA mutations interfere with DNA fix, making carriers predisposed to develop cancer.

Eccles, MD, University of Southampton and University Hospital Southampton NHS Foundation Trust, United Kingdom, and colleagues looked at survival following treatment for the initial breast cancer diagnosed only.

While only about five percent of breast cancers are diagnosed in women younger than 40, a high proportion of deaths fall in this age category.

The BRCA1 and BRCA2 genes play a critical role maintaining the genetic stability of cells, and produce proteins responsible for repairing damaged DNA. "Understanding prognosis in young patients is important because patients with BRCA mutations are at increased risk of developing specific conditions, such as secondary cancers, including ovarian cancer, contralateral breast cancer, and de novo breast cancer in the same breast".

Eagles that are key to a victory against the Falcons
If you would like to receive an email each time a new Atlanta Falcons article is published , fill out our email notification form. Just go be Nick. "They're playing very well in the secondary, and it's going to be a good challenge for us on Saturday ".

RB Leipzig will resist Liverpool's attempts to get Naby Keita in January
Liverpool will step up their attempts to secure Naby Keita's early arrival by entering into talks with RB Leipzig . The reason they need to land a big signing is not only about replacing Coutinho in the team, either.

Shanghai stocks gain for 11th day as consumer and financials rise
In other commodities , the Brent crude oil spot price was up by 0.2% to $69.26 per barrel as of 11:10 am Shanghai time. The dollar then rallied and was up as much as 0.4 percent before slipping back to trade 0.2 percent up at 111.69 yen.

On Thursday, research led by the University of Southampton concluded that BRCA-mutated breast cancer is no more unsafe or aggressive than any other form of the disease.

But the study by the University of Southampton, of women between the ages of 18 and 40 years, found after treatment, there was no significant difference is survival rate between women who have a faulty gene and women who do not.

The women's medical records were tracked for up to 10 years.

Patients were then followed up for an average of just over 8 years, which revealed similar survival across women in the study, regardless of their BRCA status, the researchers report in the Lancet Oncology.

The PARP inhibitor is now available to patients with deleterious or suspected germline BRCA-mutated (bBRCAm), human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer (MBC) who have been previously treated with chemotherapy in the neoadjuvant, adjuvant or metastatic setting.

The BRCA test consists of a simple blood sample, with risks and benefits to be considered.

Professor Peter Fasching, from Friedrich-Alexander University Erlangen-Nuremberg, Germany, added: "This important topic needs more prospective research as preventive surgical measures might have an effect on what might be a very long life after a diagnosis of breast cancer at a young age". It means that they can take time to discuss whether radical breast surgery is the right choice for them as part of a longer-term risk-reducing strategy.

Latest News