Former First Lady Barbara Bush, who has been battling congestive heart failure, has decided not to seek additional medical treatment and go home from a hospital to be "surrounded by a family she adores", according to a statement released Sunday by the office of former President George H.W. Bush.
Bush is the only living wife of one former President and the mother of another former President.
Both Barbara Bush and her husband, who live in Texas, have confronted numerous medical difficulties in recent years.
The short statement did not indicate the nature of Mrs Bush's illness but said that she had had a series of recent hospitalisations.
Her husband, the 41st U.S. president, is 93 years old.
Bush is 92 years old. Bush stood with her husband as their son George W. was sworn in as president.
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"One out of six Americans, literally, can not read above the fifth grade level - that's awful!", said Barbara when she made literacy her focal point while serving as First Lady of the United States.
Barbara Bush, often known for her outspoken remarks and self-deprecating wit, was the USA first lady from 1989 to 1993 when her husband was the country's 41st president.
During her time as First Lady, Barbara Bush focused on literacy.
"I have had great medical care and more operations than you would believe", she told the magazine. They got engaged right before he left to fight in World War II as a Navy pilot.
All along, Barbara Bush has been regarded as an invaluable asset with a grandmotherly persona that could belie a forthright outspokenness.
Smith College awarded Barbara Bush with an honorary degree in 1989.