And, after a year of unprecedented attacks on science, the marchers weren't afraid to get a little political.
The second edition of the march was organised in more than 200 cities across the globe attended by lakhs of scientists, research scholars, teachers and students.
In Frankfurt, according to police, about 500 people took part in protests, less than the 2,000 who had been expected.
This year's main march took place outside the National Mall in Washington, D.C, with more than 230 satellite events scheduled worldwide.
"It's time for people to be aware of what's going on", said an attendee.
Protesters at Saskatoon's March for Science gathered at the Chinese Ting in Victoria Park before marching through downtown to bring awareness to the need for scientific and evidence based approaches to policy making on April 14, 2018.
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"We need to speak up, or policy decisions will be made without scientific input", the toxicologist told CNN. Education should not be limited to scientists, she said.
At a public meeting after the march, organisers read out messages from geneticist M.S. Swaminathan and former Anna University Vice-Chancellor M. Anandakrishnan.
"Increased access to mental health services".
"Funding for science continues to remain abysmally low in India while all developed countries or those aspiring to reach that stage of development are, in keeping with requirements of the knowledge era, investing much higher proportions of GDP in S&T research", said a statement by the organisers.
Scientists' criticism of the President grew weeks later when he decided the United States would pull out of the Paris climate accord.