Monthly dose of new antibody may halve migraine attacks

A woman in pain from a migraine holding her head

Migraine the most common neurological disorder is often very difficult to treat Credit Andrew Crowley

For those given erenumab, migraine days were reduced by 1.6 times more than those given a placebo and acute medication days were reduced by 1.7 times more than participants given a placebo. It's a long-lasting injection given monthly, and it is meant to stop migraines before they begin.

Erenumab works by targeting a receptor in the brain where a protein associated with migraines would usually bind. Overall, erenumab reduced the average number of migraine headaches by more than 50 percent for almost a third of the patients, as opposed to only 14 percent in the placebo group.

The Thousand Oaks biotech said 246 patients who had experienced two to four previous preventive treatment failures were randomized to receive monthly injections of either Aimovig or a placebo for 12 weeks. This CGRP is a molecule that can transmit the signals of pain during an attack of migraine. Of the participants, 39 percent had been treated unsuccessfully with two other medications, 38 percent with three medications and 23 percent with four medications. Current medicines for migraines are often "repurposed" - meaning that they were originally created to treat other conditions, including blood pressure or epilepsy.

Patients also had a 100% reduction in monthly migraine days, and an improved physical functioning and ability to complete everyday activities as measured by the Migraine Physical Function Impact Diary (MPFID) scales, researchers found. They experienced an average of nine migraine headaches a month and took acute migraine medicine to stop an attack five times a month. The study results would be presented at the American Academy of Neurology's 70th Annual Meeting in Los Angeles, between April 21st and 27th, 2018.

Eller, Capitals beat Blue Jackets in 2OT to tighten series
The Caps had a 1-0 lead in the second period when Holtby gave up a weak goal to Columbus' Pierre-Luc Dubois. Tom Wilson and John Carlson also scored for the Capitals, and Braden Holtby stopped 33 shots.

Place your bet: Golden Knights are new favorites to win Stanley Cup
It's only the third time in North American pro sports history that a team swept its first playoff series in franchise history. He moved past Dominik Hasek into 11th place on the NHL's all-time list for playoff wins for a goaltender.

Heaps of tumbling tumbleweeds invade town
The tumbleweed, also known as the prickly Russian thistle, has been introduced across most of California, according to the USDA. A spokeswoman for the city said up to 150 homes were covered in the tumbleweed, which were brought there by 60mph winds.

What's particularly promising about erenumab is that it is the first-ever migraine drug designed for prevention. The success of available migraine prophylaxis treatments is often limited by inadequate effectiveness, adverse events and poor patient adherence partly as a result of poorly tolerated current treatment options. For some people, the attacks all but vanished.

Dr Mark Toms, Chief Scientific Officer at Novartis UK, said: "There has been no real advancement in migraine treatment for the past 20 years and we're proud to be breaking new ground in neurology for the millions of people in the UK living with the painful and disruptive symptoms of migraine".

"The people we included in our study were considered more hard to treat, meaning that up to four other preventative treatments hadn't worked for them", study author Dr. Uwe Reuter of The Charite- University Medicine Berlin in Germany said in an AAN press release.

Latest News