The four new states added to the list are Florida, Minnesota, North Dakota and Texas.
Scientists have identified a link to romaine lettuce grown in the Yuma, Arizona region.
Of the 149 reported cases, ill people range in age from 1 to 88 years, with a median age of 30, according to the CDC.
As of April, eight people from Idaho had gotten sick from E. coli.
The lettuce produced by that growing region in Arizona is no longer being grown and shipped, since the growing season is over. Restaurants and retailers are also instructed not to sell or serve romaine lettuce, and to check with their suppliers regarding where their romaine lettuce is sourced.
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- Remove the outer leaves from a head of lettuce.
Since its last update on May 2, the CDC says it has received reports of 28 more people falling ill with E. coli strain O157:H7 across four new states. Don't soak lettuce in the sink, because there may be bacteria in the sink that can contaminate it. Store lettuce in the fridge up to 7 days.
Health officials say that they are investigating the issue to get to the bottom of it and to finally determine if the contaminated romaine lettuce is in the Canadian market - if yes, Canadian Food Inspection Agency will recall the product as required.
According to the CDC, symptoms include bloody diarrhea and hemolytic uremic syndrome (HUS), a condition that can cause renal failure. It's still uncertain where in the supply chain the contamination happened.
It has added six from California, one from Florida, one from Georgia, one from IL, one from MA, 10 from Missouri, one from New Jersey, two from NY, two from North Dakota, one from Texas, one from Washington and one from Wisconsin.
"If I was a customer I would just make sure to continue to watch the news ... you never can be too careful", Barnes said.