Fury (26-0, 19 KO) is next scheduled to fight on August 18 in Belfast against an opponent yet to be named.
Frank Warren, promoter to both Fury and Frampton, confirmed that the heavyweight would appear on the Belfast bill as he continues his comeback.
After the layoff, during which he put on eight stones and suffered from depression, Fury showed he is still in business but it was not fluent until he began swatting his considerably smaller and lighter opponent around the ring in the fourth round.
After much talk about how good he is going to be, including comparing himself to Muhammad Ali and Floyd Mayweather, Fury did not encounter much difficulty in forcing the outsized Seferi to quit before the fifth round at Manchester Arena.
As he targets a return to the big-time he briefly left after dethroning Wladimir Klitschko so memorably in November 2015, Fury will surely have no more nights quite so farcical as his triumph over Seferi.
If he looked a little more serious from the second round onwards, it still felt like something of a non-event as the limited Seferi tried in vain to even reach Fury's head with his sluggish right uppercuts.
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I learned two and a half years is a long time to be out.
Seferi, who was almost five stones lighter and seven inches smaller, did show some ambition early on but Fury's height and movement ensured there was never going to be an upset at Manchester Arena.
"I'm sure Frank's going to keep me busy and the calibre of opponents will keep rising". He needs to get the ring rust off.
Fury has plans to regain his three world titles, now in the possession of English rival Anthony Joshua, and his one potential future opponent could be Germany's Manuel Charr who was ringside.
But just boxing again seemed unlikely at times for Fury during a troublesome period away from boxing.
Fury was eventually given a backdated two-year ban for testing positive for the banned steroid nandrolone and in exile he piled on the pounds while the WBA, WBO and IBF titles slipped into the hands of others.