Callum Hudson-Odoi was tipped to start after a bright preseason.
But there was no instant return on that investment as Jeffrey Schlupp and Wilfried Zaha scored either side of half-time to give Palace a 2-0 win at Craven Cottage.
Another positive was the performance of Alvaro Morata, much maligned for his form in the second half of last season, and heavily linked with a move away from Chelsea this summer.
Had Mounie levelled with Huddersfield 1-0 down, rather than heading against the post after Mathias Jorgensen had flicked on Aaron Mooy's corner, perhaps Sarri's afternoon would have been far more uncomfortable.
Wagner's Terriers could find more joy playing against the top flight's weaker sides if they continue in like manner.
"I don't know, he has always kicked the penalty like this", Sarri shrugged.
STAR MAN - Mounie seemed the most likely to hurt the visiting Londoners and came quite close to equalising after Kante scored in the first half. "They left everything on the pitch, but Chelsea showed their strength and that's why we lost".
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The goals and the red card were the only notable pieces of action of the first half. Neves curled in the resulting free-kick. So he has a lot of progression.
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But Chelsea took the lead in the 34th.
Sarri has quite a task on his hands getting this Chelsea squad up to speed and there were concerns heading into the match.
Undisturbed by the pressure and jeering of the Huddersfield fans, Jorginho calmly dispatched his penalty with a skip before striking the ball - a technique some at Chelsea will have already seen in their pre-season shootouts.
Vertonghen and Alli struck either side of Joselu's equaliser for the Magpies with all three goals coming in the first 18 minutes.
Arrizabalaga 7, Azpilicueta 7, Rudiger 7, David Luiz 8, Alonso 6, Jorginho 8, Kante 8, Barkley 5, Willian 7, Pedro 8, Morata 5.
Substitutes: Caballero, Christensen, Zappacosta, Moses (N/A), Loftus-Cheek (7), Hazard (8), Giroud. It is expected that his influence will only grow, given his new, advanced role. I saw our spirit, togetherness and good attitude today, which is what we will need to be competitive this season.
Kante, however, was the standout player as the Blues opened their campaign with a 3-0 win.
The Belgian made a burst from his own half that drew Huddersfield defenders towards him before rolling a diagonal pass for Pedro to slot in the third.