The former Arsenal star has scored just three times since his January move to Old Trafford and is yet to open his account for the season.
Phil Jones could return to the squad after recovering from a hamstring injury but Marcos Rojo and Ander Herrera remain on the sidelines while Diogo Dalot will drop out despite an impressive debut in midweek.
"I want him, in this process of adaptation, to play totally fresh, so he's not playing tomorrow", said Mourinho. "He plays Tuesday again". It was a hard pitch, he recovered totally and on Tuesday he will play again. I think the team is more compact, more solid, the spirit, the cooperation, the empathy, the communication - all of that improves in the team and good results bring confidence and I think we are improving as a team. I think with my style of game I am good for this league and I think I adapt good.
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Players said Meyer appeared to be genuine in telling them some of the details of what happened and why. So once again, I can only do what I can do.
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EPL: Mourinho explains why Diogo Dalot will be dropped against Wolves
Jose Mourinho has confirmed that he is missing just two players as he prepares his team for this weekend's visit of newly promoted Wolves.
"Yes, yes, yes. Not only me, I think a lot of managers after that achieved and got the chance to come to the Premier League because they were related to Mourinho", Nuno said with Marco Silva, Andre Villas-Boas and Carlos Carvalhal all having managed in the Premier League and all having had a link to, or friendship with, Mourinho.
'Playing for Manchester United is hard enough for a kid of 19 coming from another country after an important injury and surgery. "He doesn't need to face more hard". "It is also about getting the right ones and I think they've got good young players and got also good experienced, stable players".
Marcus Rashford and Nemanja Matic will also miss the game through suspension after they were both sent off in each of United's last two league games.
Speaking at his pre-match media conference ahead of their clash against Wolves on Saturday afternoon, Mourinho highlighted some improvements his team have made. "Apart from them [and the suspended players], everyone is ready", Mourinho explained.