A recent poll conducted by Quinnipiac University showed Cruz leading O'Rourke by nine points.
Cruz and O'Rouke last week agreed to three debates.
The race between Cruz and O'Rourke has garnered national attention due to O'Rourke's unlikely popularity as a candidate.
Recent polls show that the race between Cruz and O'Rourke is relatively close for Texas, which has not sent a Democrat to the Senate since 1992.
The upscale University Park area surrounding the serene college campus where Friday night's debate will take place is exactly the type of battleground that both Cruz and O'Rourke need to perform well if they want to emerge victorious in November.
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O'Rourke has built his campaign around healthcare, economic inequality, and resisting Trump and Cruz's immigration policies, as well as calling for some gun-control measures including uniform background checks and banning high-capacity weapons.
For those who like watching with a partisan support group, the O'Rourke campaign has organized a San Antonio watch party at Burleson Beer Garden, and there's also one sponsored by the Bexar County Democratic Party.
"You see a lot more O'Rourke signs in affluent Republican-leaning areas than you might typically see for a Democratic candidate".
CNN senior writer and analyst Harry Enten lamented Friday how most polls show Rep. Beto O'Rourke (D., Texas) losing in his bid to unseat Sen. Men back Cruz 57 - 42 percent.