He finished 26 of 29 for 363 yards and three touchdowns, which left him one shy of joining Manning, Brett Favre and Tom Brady as the only quarterbacks with 500 career touchdown passes.
Any hope Washington had of coming back was all but snuffed out when Justin Hardee, a special teams regular who was in the game because of Marshon Lattimore's concussion symptoms, snagged Alex Smith's underthrown pass at the Saints' 19-yard line and returned his first career interception to the Washington 4.
The game was stopped so the moment could be recognized with Brees' family and the removal of the ball so that it could go to the Pro Football Hall of Fame.
Paired with an offensive mastermind in head coach Sean Payton, Brees produced an NFL-record five 5,000-yard passing seasons.
The No. 1 total defense had an early bye week, which should have given them more than enough time to prepare for one of its toughest matchups of the season.
Saints running backs versus Redskins linebackers: For the first time this season, New Orleans will welcome back running back Mark Ingram. Peterson briefly played for the Saints a year ago before they traded him to the Arizona Cardinals.
Child among three Palestinians killed in Gaza protests
Earlier Friday, Hamas' leader told an Israeli newspaper that another war in the Gaza Strip is "definitely not in our interest". A protester waves Palestinian national flags while others burn tires near the fence of the Gaza Strip border with Israel .
EPL: Ian Wright reveals why Arsenal must allow Ramsey leave
'The one thing that gets them out of trouble is that they're always going to score goals. I think we are in the first competition in the war.
Climate change: Could changing your lifestyle really make a difference?
Meeting the 1.5C limit would demand "rapid, far-reaching and unprecedented change in all aspects of society", the panel said. The report notes that we are now at a warming of about 1.0°C, with the warming trend rolling along at 0.2±0.1°C per decade.
Following a score from the New Orleans Saints on their opening drive, the Redskins set out on their second drive trailing 6-0. "There was a lot of jabbering going on between both teams there for a little while, but we have to rise above it and understand that there's ramifications if you get in a pushing and shoving match after a play". And I absolutely understand the coaches on this staff have to coach better. The 53-yard kick was the sixth make over 50 yards in his career.
Brees also connected with Smith on a 35-yard touchdown pass on the first series of the second half.
Norman's defensive holding penalty during Brees' incomplete pass sustained the Saints' first scoring drive, capped by Ingram's short touchdown run.
Smith finished with three catches for 111 yards. Earlier in the second quarter, he found tight end Josh Hill for a 1-yard flip in the back of the end zone. Gruden also said running back Adrian Peterson has a shoulder strain and will have an MRI.
Vernon Davis has a hamstring injury.
Saints: Enter their bye week before returning to action at Baltimore on October 21.