Star Indian pacers Jasprit Bumrah and Bhuvneshwar Kumar have also not been included for the first two ODIs.
The ODI series against West Indies begins on October 21 in Guwahati before moving to Visakhapatnam on October 24.
"Of course Umesh Yadav is also part of our pool and as we are looking at a workload management strategy". Since the end of the 2015 World Cup, India have tried 11 players at this position but Prasad said "we are very close" to finalising India's best options in the middle order. "Only in case of an emergency, Pant will keep wicket", he said.
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The 15-man squad also sees the return of Virat Kohli as captain after he sat out of the Asia Cup recently. "We have given a few opportunities to Karthik".
Ambati Rayudu and MS Dhoni will play for Hyderabad and Jharkhand respectively in the knockout phase of the Vijay Hazare Trophy beginning on October 14, he said. Jadhav will come back after the first two ODIs, and Pandya will be fit from the second week of November. Raina could have been the flawless No.6 batsman who can take up Jadhav's position for the West Indies series. Notably, he had played all the matches in the Asia Cup.
Ravindra Jadeja, who was drafted into the Asia Cup squad after an injury to Axar Patel, has kept his place as has left-arm pace bowler Khaleel Ahmed.
Virat Kohli (Capt), Rohit Sharma (vc), Shikhar Dhawan, Ambati Rayudu, Manish Pandey, MS Dhoni (wk), Rishabh Pant, R Jadeja, Yuzvendra Chahal, Kuldeep Yadav, Mohammed Shami, Khaleel Ahmed, Shardul Thakur, and KL Rahul.