According to his daughter who contributed in the completion of the book, Hawking noted people wanted answers from him on specific questions.
In the book, Hawking answers other major questions, such as whether we can predict the future (in principle yes, in practice no), if time travel is possible (he can't rule it out), and if there's other intelligent life in the universe (yes).
Dr Hawking was known for bringing clarity to some of the most mind-bending ideas in science such as the nature of black holes and the possibility of a multiverse.
"There is no God".
This forecast is contained in the book "Short answers to big questions", which Hawking worked shortly before his death, according to Medusa.
"For centuries, it was believed that disabled people like me were living under a curse that was inflicted by God", he adds.
As Cnet reported, Hawking goes on to say in his book that the realisation about God made him to decide that belief in an afterlife was just "wishful thinking" and that "when we die, we return to dust".
The 76-year-old Cambridge University professor suffered from muscle-wasting disease amyotrophic lateral sclerosis (ALS) that left him wheelchair bound and unable to communicate without the help of a machine for much of his life.
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It has been completed by the theoretical physicist's family and academic colleagues, with material drawn from his vast personal archive. To which Hawking states, "There is no God".
"We need to employ effective management in all areas of its development", he said.
He wrote that the time traveling will be unsuccessful due to the expensiveness and the lack of founds.
"We are now entering a new phase of what might be called self-designed evolution, in which we will be able to change and improve our DNA", Hawking writes.
Now deceased British scientist Stephen Hawking and his daughter Lucy Hawking arrive on the red carpet for the 2015 British Academy Film Awards ceremony at The Royal Opera House in London, Britain in 2015.
She added that her father felt that it more important than ever before for young people to be educated in science and technology "so they did not feel disenfranchised by the modern world". A critic of Brexit and of Donald Trump, Hawking increasingly expressed dismay at how divided the world is seemingly becoming. "The basis for the future of education must lie in schools and inspiring teachers".
Hawking's final message to readers, though, is a hopeful one.
His final prediction is set to be released in a new book of his essays, named Brief Answers to Big Questions.