In a statement, the USA military said a strike last week near Harardere, Somalia, killed "approximately sixty terrorists".
In November 2017, more than 100 militants from Islamist Al-Shabaab group were killed in a United States airstrike, Reuters reported.
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The US military has carried out more than two dozen air strikes, including drone strikes, this year against the al-Qaeda-linked al-Shabab. Washington says its attacks target militants groups. A US Africa Command spokesperson said Friday's airstrike had no link to the anniversary.
In June, a US Special Operations forces soldier, Staff Sgt Alexander W Conrad, 26, of Chandler, Arizona, was killed, and four others were wounded, in an attack in southwestern Somalia against al-Shabab fighters, three Defence Department officials said.
AFRICOM said that they are committed to preventing al-Shabaab from taking advantage of safe havens from which they can build capacity and attack the people of Somalia.
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They have been training and fighting alongside local troops in Somalia for more than a decade, and are now buttressed by invigorated airstrike authorities under the Trump administration.
American warplanes struck the Al-Shabaab-controlled area of Haradere in Mudug province, which is located in north-central Somalia.
Al-Shabaab, which seeks to establish an Islamic state in Somalia, continues to hold parts of the country's south and central regions after being chased out of Mogadishu several years ago.
Two officials tell The Associated Press that several missiles were fired Friday by two unmanned USA drones.
Somali forces in the next few years are expected to take over responsibility for the country's security from an African Union peacekeeping force, which already has started withdrawing hundreds of personnel.
At least two attacks involved United States aircraft.