The 20 Premier League clubs enter the frame, including holders Chelsea (ball number 12), as do the 24 members of the Championship.
Premier League leaders Manchester City, who were knocked out by Wigan Athletic in the fifth round last season, entertain Rotherham United.
The draw was made on Monday evening by former Magpies manager Ruud Gullit - who took Newcastle to the final in 1999 - and ex-England global Paul Ince.
Huddersfield Town, Yorkshire's sole top flight representative, head to Bristol City, while Hull City and Leeds United are bound for the capital to tackle Millwall and QPR respectively.
Rare December tornadoes reported in central US ; 1 dead
In Georgia, an apparent tornado hit Naval Submarine Base Kings Bay on Sunday, according to public affairs officer Scott Bassett. The National Weather Service reportedly deployed teams on Sunday to assess the damage and measure the strength of the twisters.
Steve Kerr takes blame: One of my worst coaching performances
They were too comfortable. "We had a lapse for a few minutes there, but that young man also made a lot of plays", Casey said. With their eighth win in 10 games, the Detroit Pistons improved to 13-7 to remain in fourth place in the Eastern Conference.
Ohio State coach Urban Meyer to retire after the Rose Bowl
And, of course, Meyer beat hated rival MI all seven times he faced them, including the last three with Jim Harbaugh as head coach. Meyer is coming off back-to-back Big Ten championships and is heading into a January 1 Rose Bowl matchup against Washington.
Tottenham, still seeking their first trophy under Mauricio Pochettino, face a trip to Merseyside against either Southport of the National League North or League Two Tranmere Rovers.
The south coast side were promoted as League Two champions in 2017 and after finishing eighth in League One this season are now leading the way under the guidance of former Wolves boss Kenny Jackett.
Liverpool were drawn away to Wolverhampton Wanderers in one of two all-English Premier League matchups in the draw for the third round of the FA Cup on Monday.