Wolves midfielder and Portugal worldwide Neves has impressed following the club's promotion, however, Guardiola insisted City can not afford the 21-year-old amid talk of a £100million fee.
Nuno Espirito Santo's side held City to a draw at Molineux earlier in the season and now sit ninth in the Premier League table.
Rui Patricio and Matt Doherty were both among the players who did not feature against the Reds last Monday, and the pair should take their place in the starting line up in this match. But of course, for the next season, it's an important target to find.
"There are many clubs in the world, many holding midfielders in the world, and majority can play here". He'll be 34 and he can not play every few days.
Guardiola has been asked numerous times if City might try to add to the squad during this month's transfer window but he remains adamant that will not happen.
And Guardiola, whose side host Wolves in the Premier League on Monday facing a seven-point gap to leaders Liverpool, encouraged De Bruyne to speak up if there is an issue.
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Guardiola acknowledges he can not expect Fernandinho, signed from Shakhtar Donetsk in 2013, to play as much for City as he gets older, adding a solution has to be found for next season. "It involves playing with two holding midfielders - not just one - but he's an excellent player".
Pep: Gundogan could be future Ferna successor: Pep Guardiola has heaped praise on Ilkay Gundogan. "The point is that a lot of them are under contracts". A month ago, I started reading - "Rúben Neves, £100m". Against Liverpool in the Cup last time out, for example, Wolves went with a midfield three of Leander Dendoncker, Ruben Neves and Joao Moutinho.
"There are players who can play in that role but, specifically Fernandinho's role, it's so hard to find".
"I would say they are incredible, top at what they are doing. We put our standards high", he says.
Guardiola said: "If he has a problem, he knows where I am, so I don't know, really". "It looks easy but it's not easy", said Guardiola. "I don't talk about players not here, never did and never will". "It's complicated, so, so complicated".