Sarries team-mate Nick Isiekwe has been called up in Itoje's place, while uncapped quartet Jack Singleton, Ben Earl, Dan Robson and Ollie Thorley are part of the squad.
The Saracens lock sustained the injury to his right knee during Saturday's impressive opening-round 32-20 win against Ireland in Dublin and was later seen leaving the Aviva Stadium on crutches. That would mean the British & Irish Lions lock would probably not return until the final match against Scotland on March 16.
"We've got Joe Launchbury ready to come back in and you saw Courtney Lawes come off the bench for us".
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"Maro's a fantastic player and a great personality around the squad".
"He's a brilliant player and he's a world-class player", England scrumhalf Danny Care, who was not named in Eddie Jones' squad, told BBC's Rugby Union Weekly.
"He's in your face, he's someone teams do not want to play against. We always look at different combinations and we'll be doing that over the next few days". He played all 80 minutes plus a club game for Saracens before the knee swelled up and the injury was discovered.
Meanwhile, two days after helping England record the greatest victory of the Jones era, Mark Wilson was brought down to earth through a shift of changing nappies.