'You've got Garry Ringrose playing well, Peter O'Mahony coming back.
Wales will look to secure their first Grand Slam win since 2012 while Joe Schmidt's Ireland will look to keep their faint championship hopes alive and will need to rely on some help from Scotland against England if they are to defend their crown.
But England are waiting to pounce knowing that if Wales falter then victory over Scotland in the finale to the tournament at Twickenham would propel them to the title.
They can emulate the all conquering 2007 team, which included the likes of Keith Earls, Cian Healy and Andrew Conway, the only Irish side to win a Grand Slam at this level.
There are a couple of changes to the forwards as lock Tadhg Beirne makes his Six Nations debut in place of the injured Iain Henderson.
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"I think he knows these players pretty well". And that's been a really positive challenge for us throughout the Six Nations, and still try to get some cohesion.
"With that combination, I do think he is as ready as we can get him to be at this stage and I know he's incredibly motivated to be as ready as he can be".
O'Brien's fellow veteran full-back Rob Kearney has recovered from a calf injury, which ruled him out on the morning of the France game, to return and his dependability under the high ball will be crucial.
Munster duo Niall Scannell, Dave Kilcoyne plus Andrew Porter cover the front row off the bench, with Ultan Dillane and Conan the other forward replacements.
The inclusion of Rob Kearney at fullback means Jordan Larmour will be on a bench which includes three Connacht players - Roux, Kieran Marmion and Jack Carty.